Article
Viral outcome of simian-human immunodeficiency virus SHIV-89.6P adapted to cynomolgus monkeys.
Archives of virology - 1 Jan 2008
Borsetti A, Baroncelli S, Maggiorella M T, Bellino S, Moretti S, Sernicola L, Belli R, Ridolfi B, Farcomeni S, Negri D R M, Cafaro A, Ensoli B, Titti F
Abstract excerpt
Simian-human immunodeficiency virus (SHIV) 89.6P is considered to be one of the most pathogenic chimeric viruses in rhesus macaques. However, when crossing from one to another species of monkeys the pathogenicity of this virus may be affected. By using SHIV-89.6P(cy243), a virus obtained by passaging SHIV-89.6P in cynomolgus macaques, we investigated the dynamics of viral replication and the impact of the...
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