Article
Comparison of the replication and persistence of simian-human immunodeficiency viruses expressing Vif proteins with mutation of the SLQYLA or HCCH domains in macaques.
Virology - 1 Sept 2010
Schmitt Kimberly, Hill M Sarah, Liu Zhenqian, Ruiz Autumn, Culley Nathan, Pinson David M, Stephens Edward B
Abstract excerpt
The Vif protein of primate lentiviruses interacts with APOBEC3 proteins, which results in shunting of the APOBEC3-Vif complex to the proteosome for degradation. Using the simian-human immunodeficiency virus (SHIV)/macaque model, we compared the replication and pathogenicity of SHIVs that express a Vif protein in which the entire SLQYLA (SHIV(Vif5A)) or HCCH (SHIV(VifHCCH(-))) domains were substituted with alanine...
Topics
- Animals
- Antibodies, Viral
- Cell Line
- Gene Products, vif
- HIV-1
- Humans
- Lymphocytes
- Macaca mulatta
- Mutagenesis, Site-Directed
- Mutation
- Protein Structure, Tertiary
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus