Article
Chronology of genetic changes in the vpu, env, and Nef genes of chimeric simian-human immunodeficiency virus (strain HXB2) during acquisition of virulence for pig-tailed macaques.
Virology - 1 Sept 1998
McCormick-Davis C, Zhao L J, Mukherjee S, Leung K, Sheffer D, Joag S V, Narayan O, Stephens E B
Abstract excerpt
Recently, we developed a highly pathogenic variant of simian-human immunodeficiency virus, SHIV-4 (containing the tat, rev, vpu, and env of the HXB2 strain of HIV-1 in a genetic background of SIVmac239), through a series of four bone marrow-bone marrow passages-first in rhesus monkeys and then in...
Topics
- Amino Acids
- Animals
- CD4 Lymphocyte Count
- Cell Line
- Consensus Sequence
- Gene Products, env
- Gene Products, nef
- Genetic Variation
- HIV
- HIV Envelope Protein gp120
- HIV Infections
- Human Immunodeficiency Virus Proteins
- Macaca mulatta
- Macaca nemestrina