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Rapid method for determination of DNA repair capacity in human peripheral blood lymphocytes amongst smokers

18 Aug 2010

Abstract excerpt

BACKGROUND: DNA repair capacity is an important determinant of susceptibility to cancer. The hOGG1 enzyme is crucial for repairing the 8-oxoguanine lesion that occurs either as a byproduct of oxidative metabolism or as a result of exogenous sources such as exposure to cigarette smoke. It has been previously reported that smokers with low hOGG1 activity had significantly higher risk of developing lung cancer as...

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PMID: 20718982
DOI: 10.1186/1471-2407-10-439

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