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Article

Large-scale investigation of base excision repair genetic polymorphisms and lung cancer risk in a multicenter study.

Journal of the National Cancer Institute - 20 Apr 2005

Hung Rayjean J, Brennan Paul, Canzian Federico, Szeszenia-Dabrowska Neonila, Zaridze David, Lissowska Jolanta, Rudnai Peter, Fabianova Eleonora, Mates Dana, Foretova Lenka, Janout Vladimir, Bencko Vladimir, Chabrier Amelie, Borel Stephane, Hall Janet, Boffetta Paolo

Abstract excerpt

BACKGROUND: Base excision repair (BER) is a highly conserved essential mechanism for maintaining genome integrity. We examined associations among four well-characterized polymorphisms of BER genes (OGG1 Ser326Cys, XRCC1 Arg194Trp, XRCC1 Arg280His, and XRCC1 Arg399Gln) and lung cancer risk. METHODS: A total of 2188 patients with lung cancer and 2198 control subjects without lung cancer recruited at 15 centers in...

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Source

Identifiers

PMID: 15840879
DOI: 10.1093/jnci/dji101

Genes

XRCC1
OGG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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