Article
Quantification of single nucleotide polymorphisms by automated DNA sequencing.
Biochemical and biophysical research communications - 19 Sept 2003
Qiu Ping, Soder George J, Sanfiorenzo Vincent J, Wang Luquan, Greene Jonathan R, Fritz Mary Ann, Cai Xiao-Yan
Abstract excerpt
Single nucleotide polymorphisms (SNPs) are linked to phenotypes associated with diseases and drug responses. Many techniques are now available to identify and quantify such SNPs in DNA or RNA pools, although the information on the latter is limited. The majority of these methodologies require prior knowledge of target sequences, normally obtained through DNA sequencing. Direct quantitation of SNPs from DNA...
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