Article
Reproductive factors and ovarian cancer risk in Jewish BRCA1 and BRCA2 mutation carriers (United States).
Cancer causes & control : CCC - 1 Jun 2003
Modugno Francesmary, Moslehi Roxana, Ness Roberta B, Nelson Deborah Brooks, Belle Steven, Kant Jeffrey A, Wheeler James E, Wonderlick Aimee, Fishman David, Karlan Beth, Risch Harvey, Cramer Daniel W, Dube Marie-Pierre, Narod Steven A
Abstract excerpt
OBJECTIVE: To determine whether oral contraceptive (OC) use, childbearing, breastfeeding and tubal ligation differ between ovarian cancer cases with and without a BRCA1/2 mutation. METHODS: A case-only study of 242 Jewish women with invasive epithelial ovarian cancer. Women were genotyped for three Ashkenazi founder mutations (185delAG and 5382insC in BRCA1 and 6174delT in BRCA2). We obtained data on OC use,...
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