Article
Reproductive and hormonal factors, and ovarian cancer risk for BRCA1 and BRCA2 mutation carriers: results from the International BRCA1/2 Carrier Cohort Study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 2009
Antoniou Antonis C, Rookus Matti, Andrieu Nadine, Brohet Richard, Chang-Claude Jenny, Peock Susan, Cook Margaret, Evans D Gareth, Eeles Rosalind, Nogues Catherine, Faivre Laurence, Gesta Paul, van Leeuwen Flora E, Ausems Margreet G E M, Osorio Ana, Caldes Trinidad, Simard Jacques, Lubinski Jan, Gerdes Anne-Marie, Olah Edith, Fürhauser Christine, Olsson Hakan, Arver Brita, Radice Paolo, Easton Douglas F, Goldgar David E
Abstract excerpt
BACKGROUND: Several reproductive and hormonal factors are known to be associated with ovarian cancer risk in the general population, including parity and oral contraceptive (OC) use. However, their effect on ovarian cancer risk for BRCA1 and BRCA2 mutation carriers has only been investigated in a small number of studies. METHODS: We used data on 2,281 BRCA1 carriers and 1,038 BRCA2 carriers from the International...
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