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Identification of a Novel Hypoxia-Inducible Factor 1-Responsive Gene, <i>RTP801</i> , Involved in Apoptosis

1 Apr 2002

Abstract excerpt

Hypoxia is an important factor that elicits numerous physiological and pathological responses. One of the major gene expression programs triggered by hypoxia is mediated through hypoxia-responsive transcription factor hypoxia-inducible factor 1 (HIF-1). Here, we report the identification and cloning of a novel HIF-1-responsive gene, designated RTP801. Its strong up-regulation by hypoxia was detected both in vitro...

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PMID: 11884613
DOI: 10.1128/mcb.22.7.2283-2293.2002

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