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Article

The role of RhoA in tissue polarity and Frizzled signalling.

Nature - 15 May 1997

Strutt D I, Weber U, Mlodzik M

Abstract excerpt

The tissue polarity genes of Drosophila are required for correct establishment of planar polarity in epidermal structures, which in the eye is shown in the mirror-image symmetric arrangement of ommatidia relative to the dorsoventral midline. Mutations in the genes frizzled (fz), dishevelled (dsh) and prickle-spiny-legs (pk-sple) result in the loss of this mirror-image symmetry. fz encodes a serpentine...

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PMID: 9153394
DOI: 10.1038/387292a0

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SRF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of RhoA in tissue polarity and Frizzled signalling.PMID 9153394Read ↗

Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling.Semantic proximity Read ↗

Dishevelled is a component of the frizzled signaling pathway in Drosophila.Semantic proximity Read ↗

The Drosophila tissue polarity gene starry night encodes a member of the protocadherin family.Semantic proximity Read ↗

Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye.Semantic proximity Read ↗

Planar polarity from flies to vertebrates.Semantic proximity Read ↗

The frizzled/stan pathway and planar cell polarity in the Drosophila wing.Semantic proximity Read ↗

Rho1 has multiple functions in Drosophila wing planar polarity.Semantic proximity Read ↗

Nonautonomous planar polarity patterning in Drosophila: dishevelled-independent functions of frizzled.Semantic proximity Read ↗

The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled receptor in planar polarity signaling.Semantic proximity Read ↗

Novel regulators of planar cell polarity: a genetic analysis in Drosophila.Semantic proximity Read ↗

A Novel Frizzled-Based Screening Tool Identifies Genetic Modifiers of Planar Cell Polarity in Drosophila Wings.Semantic proximity Read ↗

Asymmetric localization of frizzled and the determination of notch-dependent cell fate in the Drosophila eye.Semantic proximity Read ↗

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