Article
A new HLA-B44 variant (B44BO [B*4408]) identified by serology.
Tissue antigens - 1 Jul 1997
Darke C, Street J, Fussell H, Thomas M, Guttridge M, Goldberg T E, Arnett K L, Parham P
Abstract excerpt
Using HLA serology, we detected a new variant of HLA-B44- B44BO- in two families. This antigen reacts with B44 antisera and is negative with over one-third of B12 (B44, B45) sera but reacts with 50% antisera with a B62 component, especially if they contain anti-B57. The variant, B*4408, differs from the common B*4402 by 4 nucleotide substitutions in exon 2: 193, 206 and 209, which produce changes in the the alpha...
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