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Article

Role of AcrR and ramA in fluoroquinolone resistance in clinical Klebsiella pneumoniae isolates from Singapore.

Antimicrobial agents and chemotherapy - 1 Sept 2003

Schneiders T, Amyes S G B, Levy S B

Abstract excerpt

The MICs of ciprofloxacin for 33 clinical isolates of K. pneumoniae resistant to extended-spectrum cephalosporins from three hospitals in Singapore ranged from 0.25 to >128 microg/ml. Nineteen of the isolates were fluoroquinolone resistant according to the NCCLS guidelines. Strains for which the ciprofloxacin MIC was >or=0.5 microg/ml harbored a mutation in DNA gyrase A (Ser83-->Tyr, Leu, or IIe), and some had a...

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Identifiers

PMID: 12936981
DOI: 10.1128/AAC.47.9.2831-2837.2003
PMCID: PMC182603

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Source receipt: pubmed, retrieved 7 Sept 2026.

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