Article
BclI polymorphism of the glucocorticoid receptor gene is associated with decreased bone mineral density in patients with endogenous hypercortisolism.
Clinical endocrinology - 1 Nov 2009
Szappanos Agnes, Patócs Attila, Tõke Judit, Boyle Belema, Sereg Márta, Majnik Judit, Borgulya Gábor, Varga Ibolya, Likó István, Rácz Károly, Tóth Miklós
Abstract excerpt
OBJECTIVE: The hypothalamic-pituitary-adrenal axis setpoint and the glucocorticoid sensitivity of various tissues are at least partially genetically determined. We investigated the impact of glucocorticoid receptor (GR) gene polymorphisms, including the BclI, N363S, ER22/23EK and A3669G variants...
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