Article
A major locus conferring susceptibility to infection by Streptococcus pneumoniae in mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jul 2003
Denny Paul, Hopes Elaine, Gingles Neill, Broman Karl W, McPheat William, Morten John, Alexander Janet, Andrew Peter W, Brown Steve D M
Abstract excerpt
We have studied the genetics of susceptibility to infection by Streptococcus pneumoniae in mice. Linkage analysis of the F(2) generation from a cross between resistant BALB/cO1aHsd and susceptible CBA/CaO1aHsd strains allowed us to map a major locus controlling the development of bacteremia and survival after intranasal infection.
Topics
- Animals
- Crosses, Genetic
- Genetic Linkage
- Genetic Predisposition to Disease
- Mice
- Mice, Inbred BALB C
- Mice, Inbred CBA
- Pneumococcal Infections
- Streptococcus pneumoniae