Article
Collaborative Cross mice have diverse phenotypic responses to infection with Methicillin-resistant Staphylococcus aureus USA300.
PLoS genetics - 1 May 2024
Nagarajan Aravindh, Scoggin Kristin, Gupta Jyotsana, Aminian Manuchehr, Adams L Garry, Kirby Michael, Threadgill David, Andrews-Polymenis Helene
Abstract excerpt
Staphylococcus aureus (S. aureus) is an opportunistic pathogen causing diseases ranging from mild skin infections to life threatening conditions, including endocarditis, pneumonia, and sepsis. To identify host genes modulating this host-pathogen interaction, we infected 25 Collaborative Cross (CC) mouse strains with methicillin-resistant S. aureus (MRSA) and monitored disease progression for seven days using a...
Topics
- Animals
- Methicillin-Resistant Staphylococcus aureus
- Staphylococcal Infections
- Mice
- Female
- Male
- Collaborative Cross Mice
- Phenotype
- Host-Pathogen Interactions
- Quantitative Trait Loci
- Disease Models, Animal