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Article

Pharmacokinetics of metoprolol enantiomers in Chinese subjects of major CYP2D6 genotypes.

Clinical pharmacology and therapeutics - 1 Apr 1999

Huang J, Chuang S K, Cheng C L, Lai M L

Abstract excerpt

OBJECTIVE: CYP2D6 mediates both alpha-hydroxylation and O-demethylation of metoprolol. In Chinese subjects, CYP2D6*1 (the wild-type) alleles are relatively uncommon. Subjects with P34S (C188-->T188) and S486T (G4268-->C4268) mutations (CYP2D6J or CYP2D6*10A) are more frequently seen. Recently, the CYP2D6*2 (CYP2D6L) genotype that results in R296C (C2938-->T2938) and S486T mutations was also found important. In...

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PMID: 10223777
DOI: 10.1016/S0009-9236(99)70134-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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