Article
Understanding V(D)J recombination initiator RAG1 gene using molecular phylogenetic and genetic variant analyses and upgrading missense and non-coding variants of clinical importance.
Biochemical and biophysical research communications - 10 Jul 2015
Kumar Abhishek, Bhandari Anita, Sarde Sandeep J, Muppavarapu Sekhar, Tandon Ravi
Abstract excerpt
The recombination-activating genes (RAGs) encode for V(D)J recombinases responsible for rearrangements of antigen-receptor genes during T and B cell development, and RAG expression is known to correlate strictly with the process of rearrangement. There have been several studies of RAG1 illustrating biochemical, physiological and immunological properties. Hitherto, there are limited studies on RAG1 focusing...
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