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Deletion of the BH3-only protein <i>puma</i> protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice

11 Dec 2007

Abstract excerpt

BH3-only proteins couple diverse stress signals to the evolutionarily conserved mitochondrial apoptosis pathway. Previously, we reported that the activation of the BH3-only protein p53-up-regulated mediator of apoptosis (Puma) was necessary and sufficient for endoplasmic reticulum (ER) stress- and proteasome inhibition-induced apoptosis in neuroblastoma and other cancer cells. Defects in protein quality control...

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PMID: 18077368
DOI: 10.1073/pnas.0707906105

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