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Article

Blocking pore-open mutants of CLC-0 by amphiphilic blockers.

The Journal of general physiology - 1 Jan 2009

Zhang Xiao-Dong, Tseng Pang-Yen, Yu Wei-Ping, Chen Tsung-Yu

Abstract excerpt

The blockade of CLC-0 chloride channels by p-chlorophenoxy acetate (CPA) has been thought to be state dependent; the conformational change of the channel pore during the "fast gating" alters the CPA binding affinity. Here, we examine the mechanism of CPA blocking in pore-open mutants of CLC-0 in which the residue E166 was replaced by various amino acids. We find that the CPA-blocking affinities depend upon the...

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Identifiers

PMID: 19088381
DOI: 10.1085/jgp.200810004
PMCID: PMC2606940

Genes

CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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