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Article

Conformational changes in the pore of CLC-0.

The Journal of general physiology - 1 Sept 2003

Accardi Alessio, Pusch Michael

Abstract excerpt

The Torpedo Cl- channel, CLC-0, is inhibited by clofibric acid derivatives from the intracellular side. We used the slow gate-deficient mutant CLC-0C212S to investigate the mechanism of block by the clofibric acid-derivative p-chlorophenoxy-acetic acid (CPA). CPA blocks open channels with low aff...

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Identifiers

PMID: 12913090
DOI: 10.1085/jgp.200308834
PMCID: PMC2234480

Genes

CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12913090-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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