Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aberrant promoter methylation and loss of suppressor of cytokine signalling-1 gene expression in the development of uterine cervical carcinogenesis.

Cellular oncology (Dordrecht, Netherlands) - 1 Dec 2011

Sobti R C, Singh Neha, Hussain Showket, Suri Vanita, Nijhawan Raje, Bharti A C, Bharadwaj Mausumi, Das B C

Abstract excerpt

BACKGROUND: Cervical cancer is a leading cause of cancer related deaths in women worldwide caused due to infection of high-risk human papillomaviruses. As JAK/STAT signalling pathway has been shown to play an important role during carcinogenesis, we studied the role of silencing of Suppressor of Cytokine Signalling-1 (SOCS-1) gene, a negative regulator of JAK/STAT pathway in cervical cancer. METHODS: The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Methylation
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to In Vitro Techniques

Share to Papillomaviridae

Share to Promoter Regions, Genetic

Share to Suppressor of Cytokine Signaling 1 Protein

Share to Suppressor of Cytokine Signaling Proteins

Share to Uterine Cervical Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 21935712
DOI: 10.1007/s13402-011-0056-2
PMCID: PMC12995090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aberrant promoter methylation and loss of suppressor of cytokine signalling-1 gene expression in the development of uterine cervical carcinogenesis.PMID 21935712Read ↗

Methylation-mediated gene silencing of suppressor of cytokine signaling-1 (SOCS-1) gene in esophageal squamous cell carcinoma patients of Kashmir valleySemantic proximity Read ↗

Suppressor of Cytokine Signaling (SOCS) Genes Are Silenced by DNA Hypermethylation and Histone Deacetylation and Regulate Response to Radiotherapy in Cervical Cancer CellsSemantic proximity Read ↗

Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasmsSemantic proximity Read ↗

The RASSF1A tumor suppressor gene is commonly inactivated in adenocarcinoma of the uterine cervix.Semantic proximity Read ↗

Suppressor of cytokine signalling‐1 gene silencing in acute myeloid leukaemia and human haematopoietic cell linesSemantic proximity Read ↗

Constitutional activation of IL-6-mediated JAK/STAT pathway through hypermethylation of SOCS-1 in human gastric cancer cell lineSemantic proximity Read ↗

Role of SOCS1 in tumor progression and therapeutic applicationSemantic proximity Read ↗

Hypermethylation-associated Inactivation of the SOCS-1 Gene, a JAK/STAT Inhibitor, in Human Pancreatic CancersSemantic proximity Read ↗

SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancerSemantic proximity Read ↗

Hypermethylation of two consecutive tumor suppressor genes, BLU and RASSF1A, located at 3p21.3 in cervical neoplasias.Semantic proximity Read ↗

Hypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patients.Semantic proximity Read ↗

Epigenetic alteration of the SOCS1 gene in hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.