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Article

Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis.

The Journal of clinical investigation - 1 Feb 2004

Ozawa Clare R, Banfi Andrea, Glazer Nicole L, Thurston Gavin, Springer Matthew L, Kraft Peggy E, McDonald Donald M, Blau Helen M

Abstract excerpt

Use of long-term constitutive expression of VEGF for therapeutic angiogenesis may be limited by the growth of abnormal blood vessels and hemangiomas. We investigated the relationship between VEGF dosage and the morphology and function of newly formed blood vessels by implanting retrovirally trans...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14966561
DOI: 10.1172/JCI18420
PMCID: PMC338257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14966561-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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