Article
Oncogenic ras fails to restore an in vivo tumorigenic phenotype in embryonic stem cells lacking vascular endothelial growth factor (VEGF).
Biochemical and biophysical research communications - 19 Jan 1999
Shi Y P, Ferrara N
Abstract excerpt
Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis. Previous studies have shown that the ability of murine embryonic stem (ES) cells to form teratocarcinomas in nude mice is substantially reduced following targeted inactivation of the VEGF gene. We sought to determine...
Topics
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- Endothelial Growth Factors
- Genes, ras
- Lymphokines
- Mice
- Mice, Knockout
- Mice, Nude
- Mice, Transgenic
- Neoplasms, Experimental
- Phenotype
- Proto-Oncogene Proteins p21(ras)
- Rats
- Stem Cells
- Transfection
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors