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Article

Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2005

Hetherington Simon L, Singh Ravi K, Lodwick David, Thompson John R, Goodall Alison H, Samani Nilesh J

Abstract excerpt

OBJECTIVE: The platelet ADP receptors P2Y1 and P2Y12 play a pivotal role in platelet aggregation. There is marked interindividual variation in platelet response to ADP. We studied whether genetic variants in the P2Y1 or P2Y12 genes affect platelet response to ADP. METHODS AND RESULTS: The P2Y1 and P2Y12 genes were screened for polymorphisms. Associations between selected polymorphisms and the platelet response to...

Topics

Adenosine Diphosphate
Adult
Cohort Studies
Female
Genotype
Humans
Male
Membrane Proteins
Middle Aged
Platelet Activation
Platelet Aggregation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Receptors, Purinergic P2

Receptors, Purinergic P2Y1

Receptors, Purinergic P2Y12

Receptors, Thrombin

Source

Identifiers

PMID: 15514209
DOI: 10.1161/01.ATV.0000148708.44691.27

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15514209-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP.PMID 15514209Read ↗

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