Article
The impact of microsatellite instability on the molecular phenotype of colorectal tumors.
Cancer research - 1 Aug 2003
Mori Yuriko, Selaru Florin M, Sato Fumiaki, Yin Jing, Simms Lisa A, Xu Yan, Olaru Andreea, Deacu Elena, Wang Suna, Taylor Jennifer M, Young Joanne, Leggett Barbara, Jass Jeremy R, Abraham John M, Shibata David, Meltzer Stephen J
Abstract excerpt
Frequent microsatellite instability MSI (MSI-H) occurring in human tumors is characterized by defective DNA mismatch repair and unique clinical features. However, infrequent MSI (MSI-L) has not been attributable to any other defined molecular pathway, and its existence as a biologically distinct...
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