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Article

Secreted LasA of Pseudomonas aeruginosa is a staphylolytic protease.

The Journal of biological chemistry - 5 Apr 1993

Kessler E, Safrin M, Olson J C, Ohman D E

Abstract excerpt

Full expression of the elastolytic phenotype of Pseudomonas aeruginosa depends on LasA, an extracellular protease with restricted specificity whose mode of action on elastin and biological role is not understood. LasA exhibits amino acid sequence homology to some bacteriolytic proteases and shares several physicochemical properties with the staphylolytic protease of P. aeruginosa. This led us to examine whether...

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PMID: 8463280

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Secreted LasA of Pseudomonas aeruginosa is a staphylolytic protease.PMID 8463280Read ↗

A substitution at His-120 in the LasA protease of Pseudomonas aeruginosa blocks enzymatic activity without affecting propeptide processing or extracellular secretion.Semantic proximity Read ↗

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