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Article

KCl cotransport is an important modulator of human cervical cancer growth and invasion.

The Journal of biological chemistry - 10 Oct 2003

Shen Meng-Ru, Chou Cheng-Yang, Hsu Keng-Fu, Hsu Yueh-Mei, Chiu Wen-Tai, Tang Ming-Jer, Alper Seth L, Ellory J Clive

Abstract excerpt

Cervical cancer is a major world health problem for women, but the pathophysiology of this disease has received scant attention. Here we show that the growth and invasion of cervical cancer cells are strongly linked the expression and activity of the KCl cotransporter (KCC), an important regulator of the ionic and cellular osmotic homeostasis. Functional assays of KCl cotransport activation by osmotic swelling,...

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Identifiers

PMID: 12902337
DOI: 10.1074/jbc.M308232200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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