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Article

Impaired activity of volume-sensitive Cl- channel is involved in cisplatin resistance of cancer cells.

Journal of cellular physiology - 1 May 2007

Lee Elbert L, Shimizu Takahiro, Ise Tomoko, Numata Tomohiro, Kohno Kimitoshi, Okada Yasunobu

Abstract excerpt

The platinum-based drug cisplatin is a widely used anticancer drug which acts by causing the induction of apoptosis. However, resistance to the drug is a major problem. In this study we show that the KCP-4 human epidermoid cancer cell line, which serves as a model of acquired resistance to cisplatin, has virtually no volume-sensitive, outwardly rectifying (VSOR) chloride channel activity. The VSOR chloride...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17186499
DOI: 10.1002/jcp.20961

Genes

KCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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