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Article

Helix 8 of the ligand binding domain of the glucocorticoid receptor (GR) is essential for ligand binding.

Molecular and cellular endocrinology - 15 Jun 2015

Deng Qiong, Waxse Bennett, Riquelme Denise, Zhang Jiabao, Aguilera Greti

Abstract excerpt

Membrane association of estrogen receptors (ER) depends on cysteine palmitoylation and two leucines in the ligand binding domain (LBD), conserved in most steroid receptors. The role of this region, corresponding to helix 8 of the glucocorticoid receptor (GR) LBD, on membrane association of GR was studied in 4B cells, expressing endogenous GR, and Cos-7 cells transfected EGFP-GR constructs. 4B cells preloaded with...

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Identifiers

PMID: 25676569
DOI: 10.1016/j.mce.2015.01.044
PMCID: PMC4417367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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