Article
Lower rate of tumor necrosis factor-alpha -863A allele and higher concentration of tumor necrosis factor-alpha receptor 2 in first-degree relatives of subjects with type 2 diabetes.
Metabolism: clinical and experimental - 1 Aug 2003
Costa A, Fernández-Real J M, Vendrell J, Broch M, Casamitjana R, Ricart W, Conget I
Abstract excerpt
Allelic variants of the tumor necrosis factor-alpha (TNF-alpha) gene seem to contribute to insulin resistance increasing the transcription rate of TNF-alpha. The TNF-alpha -863A allele is associated with a lower expression of TNF-alpha gene and less secretion of the cytokine. To investigate wheth...
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