Article
Tumor necrosis factor-α (TNF-α) -863C/A promoter polymorphism is associated with type 2 diabetes in Tunisian population.
Diabetes research and clinical practice - 1 Nov 2013
Kallel Amani, Ftouhi Bochra, Jemaa Zeineb, Mahjoubi Imen, Feki Moncef, Slimane Hedia, Jemaa Riadh, Kaabachi Naziha
Abstract excerpt
AIMS: Tumor necrosis factor α (TNFα) plays a key role in orchestrating the complex events involved in inflammation and immunity. Accordingly, TNF α has been implicated in a wide range of autoimmune and infectious diseases, but also in conditions such as obesity and insulin resistance. The aim of the present study was to investigate the association between the -863C/A polymorphism in the promoter of the TNFα gene...
Topics
- Adult
- Aged
- Case-Control Studies
- Diabetes Mellitus, Type 2
- Female
- Gene Frequency
- Genotype
- Humans
- Insulin Resistance
- Logistic Models
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Genetic