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Article

Network dynamics of hypothalamic feeding neurons

1 Apr 2021

Abstract excerpt

Mutations in the melanocortin 4 receptor (MC4R) result in hyperphagia and obesity and are the most common cause of monogenic obesity in humans. Preclinical rodent studies have determined that the critical role of the MC4R in controlling feeding can be mapped in part to its expression in the paraventricular nucleus of the hypothalamus (paraventricular nucleus [PVN]), where it regulates the activity of anorexic...

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PMID: 33795520
DOI: 10.1073/pnas.2011140118

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