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Article

First demonstration of a lack of viral sequence evolution in a nonprogressor, defining replication-incompetent HIV-1 infection.

Virology - 20 Jul 2003

Wang Bin, Mikhail Meriet, Dyer Wayne B, Zaunders John J, Kelleher Anthony D, Saksena Nitin K

Abstract excerpt

It is universally acknowledged that genetic diversity is a hallmark of HIV-1 infection, and it is one of the traits that has considerably hampered the development of an effective vaccine. In a study of full-length HIV-1 genomic sequences (>9 kb), we show unique evidence for complete absence of viral evolution in an individual with truly nonprogressive infection. Gross gene defects were not detected, but the state...

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Identifiers

PMID: 12890627
DOI: 10.1016/s0042-6822(03)00159-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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