Article
Genotype/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice.
Hormones and behavior - 1 May 2002
Nomura Masayoshi, Durbak Larissa, Chan Johnny, Smithies Oliver, Gustafsson Jan-Ake, Korach Kenneth S, Pfaff Donald W, Ogawa Sonoko
Abstract excerpt
Estrogen, as an aromatized metabolite of testosterone, has a facilitatory effect on male aggressive behavior in mice. Two subtypes of estrogen receptors, alpha (ER-alpha) and beta (ER-beta), in the brain are known to bind estrogen. Previous studies revealed that the lack of ER-alpha gene severely reduced the induction of male aggressive behavior. In contrast, mice that lacked the ER-beta gene tended to be more...
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