Article
Analysis of allelic expression patterns of IL-2, IL-3, IL-4, and IL-13 in human CD4+ T cell clones.
European journal of immunology - 1 Aug 2003
Bayley Jean-Pierre, Bakker Aleida M, Kaijzel Eric L, Wierenga Eddy A, van der Pouw-Kraan Tineke C T M, Huizinga Tom W J, Verweij Cornelis L
Abstract excerpt
The occurrence of monoallelic expression of cytokine genes in single cells has been convincingly demonstrated, but there have been few reports of this phenomenon in T cell clones. Here we describe studies on the expression of alleles of the human genes encoding IL-2, IL-3, IL-4, and IL-13 in human CD4(+) T cell clones. In contrast to the results reported in mouse T cell clones and single human T cells, we found...
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