Article

ATM safeguards DNA replication at endogenous base lesions

2026-03-21

Abstract excerpt

Poly(ADP-ribose) polymerase inhibitors (PARPi) exploit homologous recombination deficiency (HRD) in BRCA1/2-mutated cancers to induce synthetic lethality 1–3 . PARPi also kill cancer cells lacking the DNA damage-responsive kinase ATM 4–6 , however, inconsistent evidence of HRD 7–9 and variable clinical responses 9–11 have obscured the underlying mechanism. Here we define how PARPi induce cytotoxicity in ATM-de...

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Literature Corpus work: 38a4ba10-479f-5803-934b-fa5590b6f135
DOI: 10.64898/2026.03.20.713105

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