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DNA breaks and chromosomal aberrations arise when replication meets base excision repair

30 Jun 2014

Abstract excerpt

Exposures that methylate DNA potently induce DNA double-strand breaks (DSBs) and chromosomal aberrations, which are thought to arise when damaged bases block DNA replication. Here, we demonstrate that DNA methylation damage causes DSB formation when replication interferes with base excision repair (BER), the predominant pathway for repairing methylated bases. We show that cells defective in the N-methylpurine DNA...

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PMID: 24982429
DOI: 10.1083/jcb.201312078

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