Article
C-C chemokine receptor 2 and sarcoidosis: association with Lofgren's syndrome.
American journal of respiratory and critical care medicine - 15 Nov 2003
Spagnolo Paolo, Renzoni Elisabetta A, Wells Athol U, Sato Hiroe, Grutters Jan C, Sestini Piersante, Abdallah Atiyeh, Gramiccioni Enzo, Ruven Henk J T, du Bois Roland M, Welsh Kenneth I
Abstract excerpt
Sarcoidosis is thought to result from the interaction between an unknown environmental antigenic trigger and the host's genetic susceptibility. We hypothesized that sarcoidosis, or one of the disease subsets, could be associated with single nucleotide polymorphisms of C-C chemokine receptor 2 (CCR2) gene. Eight single-nucleotide polymorphisms in CCR2 were studied in a total of 304 Dutch individuals (90...
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