Article
Study of C-C chemokine receptor 2 alleles in sarcoidosis, with emphasis on family-based analysis.
American journal of respiratory and critical care medicine - 15 May 2005
Valentonyte Ruta, Hampe Jochen, Croucher Peter J P, Müller-Quernheim Joachim, Schwinger Eberhard, Schreiber Stefan, Schürmann Manfred
Abstract excerpt
Prevailing models of sarcoidosis pathogenesis involve the activation of alveolar macrophages, aggregation of CD4+ T lymphocytes, and their accumulation in epithelioid cell granulomas. Increasing evidence suggests that each of these steps is modified by the host genetic constitution. Consequently, candidate susceptibility genes have been selected based on their potential function under this model. The C-C...
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