Article
ENU mutagenesis screening for dominant behavioral mutations based on normal control data obtained in home-cage activity, open-field, and passive avoidance tests.
Experimental animals - 1 Jan 2010
Wada Yumiko, Furuse Tamio, Yamada Ikuko, Masuya Hiroshi, Kushida Tomoko, Shibukawa Yoko, Nakai Yuji, Kobayashi Kimio, Kaneda Hideki, Gondo Yoichi, Noda Tetsuo, Shiroishi Toshihiko, Wakana Shigeharu
Abstract excerpt
To establish the cutoff values for screening ENU-induced behavioral mutations, normal variations in mouse behavioral data were examined in home-cage activity (HA), open-field (OF), and passive-avoidance (PA) tests. We defined the normal range as one that included more than 95% of the normal control values. The cutoffs were defined to identify outliers yielding values that deviated from the normal by less than 5%...
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