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Article

Biochemical and genetic studies of UBR3, a ubiquitin ligase with a function in olfactory and other sensory systems.

The Journal of biological chemistry - 22 Jun 2007

Tasaki Takafumi, Sohr Reinhard, Xia Zanxian, Hellweg Rainer, Hörtnagl Heide, Varshavsky Alexander, Kwon Yong Tae

Abstract excerpt

Our previous work identified E3 ubiquitin ligases, termed UBR1-UBR7, that contain the approximately 70-residue UBR box, a motif important for the targeting of N-end rule substrates. In this pathway, specific N-terminal residues of substrates are recognized as degradation signals by UBR box-containing E3s that include UBR1, UBR2, UBR4, and UBR5. The other E3s of this set, UBR3, UBR6, and UBR7, remained...

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Source

Identifiers

PMID: 17462990
DOI: 10.1074/jbc.M701894200

Genes

UBR3
UBR1
UBR2
UBR7
UBR4
UBR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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