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Article

BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC.

Oncogene - 17 Jul 2003

Soares Paula, Trovisco Vítor, Rocha Ana Sofia, Lima Jorge, Castro Patrícia, Preto Ana, Máximo Valdemar, Botelho Tiago, Seruca Raquel, Sobrinho-Simões Manuel

Abstract excerpt

Rearrangement of RET proto-oncogene is the major event in the etiopathogenesis of papillary thyroid carcinoma (PTC). We report a high prevalence of BRAF(V599E) mutation in sporadic PTC and in PTC-derived cell lines. The BRAF(V599E) mutation was detected in 23 of 50 PTC (46%) and in three of four PTC-derived cell lines. The prevalence of the BRAF(V599E) mutation in PTC is the highest reported to date in human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 12881714
DOI: 10.1038/sj.onc.1206706

Genes

BRAF
RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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