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Article

Regulation of the growth arrest and DNA damage-inducible gene 45 (GADD45) by peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells.

Circulation research - 22 Aug 2003

Bruemmer Dennis, Yin Fen, Liu Joey, Berger Joel P, Sakai Toshiyuki, Blaschke Florian, Fleck Eckart, Van Herle Andre J, Forman Barry M, Law Ronald E

Abstract excerpt

Peroxisome proliferator-activated receptor (PPAR) gamma is activated by thiazolidinediones (TZDs), widely used as insulin-sensitizing agents for the treatment of type 2 diabetes. TZDs have been shown to induce apoptosis in a variety of mammalian cells. In vascular smooth muscle cells (VSMCs), proliferation and apoptosis may be competing processes during the formation of restenotic and atherosclerotic lesions. The...

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PMID: 12881480
DOI: 10.1161/01.RES.0000088344.15288.E6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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