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Article

Macrophage migration inhibitory factor (MIF) expression in human malignant gliomas contributes to immune escape and tumour progression.

Acta neuropathologica - 1 Sept 2011

Mittelbronn Michel, Platten Michael, Zeiner Pia, Dombrowski Yvonne, Frank Brigitte, Zachskorn Cornelia, Harter Patrick N, Weller Michael, Wischhusen Jörg

Abstract excerpt

Macrophage migration inhibitory factor (MIF), which inhibits apoptosis and promotes angiogenesis, is expressed in cancers suppressing immune surveillance. Its biological role in human glioblastoma is, however, only poorly understood. We examined in-vivo expression of MIF in 166 gliomas and 23 normal control brains by immunohistochemistry. MIF immunoreactivity was enhanced in neoplastic astrocytes in WHO grade II...

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Share to Antigens, Differentiation, Myelomonocytic
Share to Glial Fibrillary Acidic Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to NK Cell Lectin-Like Receptor Subfamily K

Share to Oligodeoxyribonucleotides, Antisense

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Source

Identifiers

PMID: 21773885
DOI: 10.1007/s00401-011-0858-3

Genes

MIF

Provenance

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