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Article

Cloning of modular type I polyketide synthase genes from salinomycin producing strain of Streptomyces albus.

Bioorganic & medicinal chemistry - 5 Aug 2003

Izumikawa Miho, Murata Michio, Tachibana Kazuo, Ebizuka Yutaka, Fujii Isao

Abstract excerpt

Cloning of polyether polyketide synthase (PKS) genes for salinomycin biosynthesis was attempted from Streptomyces albus. Seven beta-ketoacyl synthase (KS) core regions were obtained by PCR amplification using primers designed based on the conserved KS domains of type I PKSs. Using the KS fragment as a probe, screening of an S. albus genomic DNA library was carried out by colony hybridization. From the positive...

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PMID: 12878134
DOI: 10.1016/s0968-0896(03)00337-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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