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The Biosynthetic Gene Cluster for the 26-Membered Ring Polyene Macrolide Pimaricin

1 Apr 1999

Abstract excerpt

The biosynthetic gene cluster for the 26-membered ring of the polyene macrolide pimaricin extends for about 110 kilobase pairs of contiguous DNA in the genome of Streptomyces natalensis. Two sets of polyketide synthase (PKS) genes are separated by a group of small polyketide-functionalizing genes. Two of the polyketide synthase genes, pimS0 and pimS1, have been fully sequenced and disrupted proving the...

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PMID: 10187796
DOI: 10.1074/jbc.274.15.10133

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