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Article

Human alveolar macrophages infected by virulent bacteria expressing SipB are a major source of active interleukin-18.

Infection and immunity - 1 Aug 2003

Obregon Carolina, Dreher Donatus, Kok Menno, Cochand Laurence, Kiama Gitahi S, Nicod Laurent P

Abstract excerpt

Recent publications have demonstrated that the protease caspase-1 is responsible for the processing of pro-interleukin 18 (IL-18) into the active form. Studies on cell lines and murine macrophages have shown that the bacterial invasion factor SipB activates caspase-1, triggering cell death. Thus, we investigated the role of SipB in the activation and release of IL-18 in human alveolar macrophages (AM), which are...

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Identifiers

PMID: 12874316
DOI: 10.1128/IAI.71.8.4382-4388.2003
PMCID: PMC166028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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