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Article

The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses

4 Oct 2018

Abstract excerpt

Inflammasomes are signaling hubs that activate inflammatory caspases to drive cytokine maturation and cell lysis. Inflammasome activation by Salmonella Typhimurium infection or Salmonella-derived molecules is extensively studied in murine myeloid cells. Salmonella-induced inflammasome signaling in human innate immune cells, is however, poorly characterized. Here, we show that Salmonella mutation to inactivate the...

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PMID: 30368901
DOI: 10.1002/jlb.ma0318-112rr

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