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Article

Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols.

Infection and immunity - 1 Aug 2003

Mukherjee Pranab K, Chandra Jyotsna, Kuhn Duncan M, Ghannoum Mahmoud A

Abstract excerpt

Candida albicans biofilms are formed through three distinct developmental phases and are associated with high fluconazole (FLU) resistance. In the present study, we used a set of isogenic Candida strains lacking one or more of the drug efflux pumps Cdr1p, Cdr2p, and Mdr1p to determine their role in FLU resistance of biofilms. Additionally, variation in sterol profile as a possible mechanism of drug resistance was...

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Source

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Identifiers

PMID: 12874310
DOI: 10.1128/IAI.71.8.4333-4340.2003
PMCID: PMC165995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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