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Article

Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains.

Antimicrobial agents and chemotherapy - 1 Dec 1998

Franz R, Kelly S L, Lamb D C, Kelly D E, Ruhnke M, Morschhäuser J

Abstract excerpt

From each of two AIDS patients with oropharyngeal candidiasis, five Candida albicans isolates from recurrent episodes of infection which became gradually resistant against fluconazole during antimycotic treatment were analyzed for molecular changes responsible for drug resistance. In both patients, a single C. albicans strain was responsible for the recurrent infections, but the CARE-2 fingerprint pattern of the...

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Identifiers

PMID: 9835492
DOI: 10.1128/AAC.42.12.3065
PMCID: PMC106000

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